Skyler is the modern American spelling of Schuyler — from the Dutch Schuylen ("to take shelter, to flee") — the surname of a prominent Dutch-American family in colonial New York. Schuyler Sisters — Eliza, Angelica, and Peggy Schuyler are immortalized in Lin-Manuel Miranda's Hamilton (2015); the "Schuyler Sisters" number is one of the most-streamed Hamilton songs.
Skyler does not currently appear in the US Social Security Administration's top 1,000 girls' names, so we don't publish a US rank or birth count for it. That says nothing about the name's standing elsewhere in the world — only that it sits outside the ranked US data we rely on.
In Pythagorean numerology the letters of Skyler reduce to 9, The Giver. This is a traditional interpretive system, not a factual claim about the name.