Isabela is from the Portuguese/Spanish Isabela — Iberian rendition of Isabella — Hebrew Elīšeḇaʿ (Elisheba — God is my oath). Isabela is among the Brazilian + Portuguese + Spanish feminine names — consistently top-5 Brazilian girls' names. What Else Can I Do? Galápagos Islands' Isabela Island is one of the ecological reserves.
Isabela does not currently appear in the US Social Security Administration's top 1,000 girls' names, so we don't publish a US rank or birth count for it. That says nothing about the name's standing elsewhere in the world — only that it sits outside the ranked US data we rely on.
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In Pythagorean numerology the letters of Isabela reduce to 4, The Builder. This is a traditional interpretive system, not a factual claim about the name.