Ismene is from the Greek Ἰσμήνη (Isménē — knowledgeable, wise). Ismene is one of the Greek feminine names — central to traditional Greek tragic heritage. Greek feminine name reflecting Greek tragic heritage.
Ismene does not currently appear in the US Social Security Administration's top 1,000 girls' names, so we don't publish a US rank or birth count for it. That says nothing about the name's standing elsewhere in the world — only that it sits outside the ranked US data we rely on.
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In Pythagorean numerology the letters of Ismene reduce to 2, The Peacemaker. This is a traditional interpretive system, not a factual claim about the name.