Louisa is the feminine of Louis — from the Old Germanic Hludwig (hlut = famous + wig = warrior). Louisa May Alcott (1832-1888) — the *American novelist whose Little Women (1868-69) became the most-read American novel by a woman in the 19th century — based on the four Alcott sisters in Concord, Massachusetts, the book has never gone out of print and has been adapted for screen at least eight times. Civil War nurse who contracted typhoid pneumonia at the Union Hotel Hospital in Georgetown, leaving her with chronic mercury poisoning from the treatment. Pseudonymously published "blood and thunder" thrillers to support her family. A passionate abolitionist and suffragist* — the first woman to register to vote in Concord.
Subject of Greta Gerwig's Little Women (2019 film).
In Pythagorean numerology the letters of Louisa reduce to 5, The Seeker. This is a traditional interpretive system, not a factual claim about the name.