Oprah is a misspelling of the biblical Orpah (Hebrew, "fawn" or "back of the neck") — Naomi's daughter-in-law in the Book of Ruth. Her 1988 "Wagon of Fat" Diet episode is the most-watched episode in talk show history.
Subject of Kitty Kelley's Oprah: A Biography (2010).
Oprah does not currently appear in the US Social Security Administration's top 1,000 girls' names, so we don't publish a US rank or birth count for it. That says nothing about the name's standing elsewhere in the world — only that it sits outside the ranked US data we rely on.
In Pythagorean numerology the letters of Oprah reduce to 4, The Builder. This is a traditional interpretive system, not a factual claim about the name.