Polyxo (Πολυξώ) combines the Greek poly (much) and xō (smooth). Queen Polyxo of Lemnos was the prophetess who, in the Argonautic tradition, had counseled the Lemnian women in their notorious massacre of the male Lemnians — when the Argonauts later arrived, she advised the women to take them as fathers of new children, repopulating the island.
Featured in Apollonius's Argonautica and Statius's Thebaid.
Polyxo does not currently appear in the US Social Security Administration's top 1,000 girls' names, so we don't publish a US rank or birth count for it. That says nothing about the name's standing elsewhere in the world — only that it sits outside the ranked US data we rely on.
In Pythagorean numerology the letters of Polyxo reduce to 8, The Visionary. This is a traditional interpretive system, not a factual claim about the name.