Roxana comes from the Old Persian Raoxshna, meaning "luminous" or "shining one" — from the same Indo-European root that gives English the word "radiance." The name was made famous by Roxana of Bactria (4th century BCE), the wife of Alexander the Great.
Roxana has been continuously used in Persian-speaking countries for two and a half millennia. Today the name sits in the U.S. top 800 and is rising — particularly in the Iranian diaspora.
Roxana does not currently appear in the US Social Security Administration's top 1,000 girls' names, so we don't publish a US rank or birth count for it. That says nothing about the name's standing elsewhere in the world — only that it sits outside the ranked US data we rely on.
In Pythagorean numerology the letters of Roxana reduce to 1, The Leader. This is a traditional interpretive system, not a factual claim about the name.