Winona comes from the Dakota Sioux Wenonah — traditionally given to a firstborn daughter. In Dakota tradition, the name is one of a set assigned by birth order. The city of Winona, Minnesota is named for a Dakota legend.
Winona was popularised by the actress Winona Ryder (born 1971), whose family named her after the city. Today Winona is rising as a girls' name in the U.S.
Winona does not currently appear in the US Social Security Administration's top 1,000 girls' names, so we don't publish a US rank or birth count for it. That says nothing about the name's standing elsewhere in the world — only that it sits outside the ranked US data we rely on.
In Pythagorean numerology the letters of Winona reduce to 4, The Builder. This is a traditional interpretive system, not a factual claim about the name.