Zissel comes from the Yiddish zis, meaning "sweet" — sharing a root with the German süß. A traditional Yiddish women's name expressing affection.
Zissel is widely used in Hasidic communities.
Zissel does not currently appear in the US Social Security Administration's top 1,000 girls' names, so we don't publish a US rank or birth count for it. That says nothing about the name's standing elsewhere in the world — only that it sits outside the ranked US data we rely on.
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In Pythagorean numerology the letters of Zissel reduce to 9, The Giver. This is a traditional interpretive system, not a factual claim about the name.